ABSTRACT
Background The natural history of recurrent pericarditis (RP) and its associated co-morbidity are not well understood. The RESONANCE registry (NCT04687358) was implemented to collect observational data from real-world clinical practice to better understand the presentation, management and outcomes of patients with RP. Methods Enrollment of adult and pediatric patients began March 2021 and continues at 22 participating centers across the US. Patients with RP episodes <=3 years prior to enrollment and currently on treatment were considered to have active disease. Patients with RP related to trauma, malignancy and connective tissue disease were excluded. The current analysis reports interim demographic and disease characteristics at enrollment for the active cohort with complete data records. Results As of 15 August 2022, complete data records were available for 100 adult and 2 pediatric patients. To date, the majority of patients are female (62%, n=64). Mean (SD) age was 47 (15) years. The primary cause of the initial acute pericarditis event was idiopathic/viral (68%, n=70) or post-cardiac injury syndrome (8%, n=8). Median (Q1,Q3) duration of disease at enrollment was 2.7 (1.0, 5.2) years. 70% (n=71) of patients had experienced at least one recurrence in the one-year retrospective period. Comorbidities were low (15%;n=16);of these, 25% (n=4) had hypertension, 25% (n=4) had cardiac arrhythmia, 25% (n=4) had depression, 12.5% (n=2) had COVID-19 and 12.5% (n=2) had anxiety. Concomitant medical management data will be presented. Conclusion RESONANCE is a novel national multicenter registry collecting data relevant for informing treatment strategies for RP. Initial data from the first 103 patients suggest a preponderance of women with active RP;overall, patients are relatively young without significant comorbidities versus other acquired cardiovascular diseases. As enrollment and data collection expands, RESONANCE is designed to reveal important characteristics for RP which can guide clinical practice and improve quality of life of patients with RP.Copyright © 2023 American College of Cardiology Foundation